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The aim of this study was to assess the efficacy and safety of Hsp90 inhibitor and methotrexate (MTX) combination therapy in rheumatoid arthritis (RA). This is a prospective study conducted at 20 centers. Patients with RA of moderate to severe activity received escalating doses of either 2 mg/kg (C1) or 5 mg/kg (C2) of AUY922 orally twice a week for 4 weeks. MTX was used 384a16bd22

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